Protein & particle distribution
Whole-brain 3D visualization of anatomical distribution of Aβ plaques[1]
Systematic whole-brain visualization of Aβ plaque distribution is critical to characterize the key pathological features for understanding the pathology of AD. The brain-wide plaque distribution from the olfactory bulb to cerebellum was clearly visualized throughout the whole 5×FAD mouse brain.
Visualization of blood vessels surrounding Aβ plaques[1]
We visualized the plaques and vasculatures simultaneously in the hippocampus. The distribution of plaques and vasculatures across the entire unilateral hippocampus showed that the plaque-denser areas in the ventral part exhibited a reduction of blood vessels; while the plaque-sparser areas in the dorsal part showed relatively richer blood vessels.
Distribution patterns of inhaled particles at full lung scale[2]
Taking advantage of the fMOST system, co-localized lung-wide datasets of both cyto-architectures and fluorescent particles are collected at full scale with the resolution down to individual particles. The precise spatial distribution pattern reveals the region-specific distribution and structure-associated deposition of the inhalable particles in lungs, which is undetected by previous methods.
Reference
[1] Yin X, Zhang X, Zhang J, et al. High-Resolution Digital Panorama of Multiple Structures in Whole Brain of Alzheimer's Disease Mice. Front Neurosci. 2022;16:870520. Published 2022 Apr 19. doi:10.3389/fnins.2022.870520
[2] Sun X, Zhang X, Ren X, et al. Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution. Adv Sci (Weinh). 2021;8(8):2003941. Published 2021 Feb 8. doi:10.1002/advs.202003941
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